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Affiliated Faculty |
Michael Boland
Assistant Professor, Wilmer Ophthalmological Institute, Johns Hopkins University
Address:
600 N. Wolfe St.
Wilmer 122
Baltimore, MD 21287
Phone: (410)
502-4074
Fax: (410)
516-5549
E-mail: boland@jhmi.edu
Research Interest Statement
The research in my lab brings engineering and computer science to bear
on problems in ophthalmology. I am specifically interested in
developing and testing tools that assist clinicians with diagnosis and
management.
Current Projects
1) The diagnosis of glaucoma is complex and requires that the clinician
synthesize information from the history, exam, and ancillary testing.
To assist the physician with diagnosis, we are currently working on
algorithms to combine the results of optic nerve imaging (structure) and
visual field tests (function). The goal of combining these tests
quantitatively is to make earlier diagnosis possible and therefore
prevent vision loss.
2) Determining a patient's risk for progressing from elevated
intraocular pressure to glaucoma (documented optic nerve damage or
vision loss) is also a complex effort. There are several risk factors
that have been identified for the progression from ocular hypertension
to glaucoma but a quantitative synthesis of these factors is beyond most
clinicians. To address this problem, we are working on developing and
testing a calculator to help clinicians assess individual patients.
Publications
Research Articles
Zhao, T., Velliste, M., Boland, M.V., Murphy R.F. 2005. Object Type
Recognition for Automated Analysis of Protein Subcellular Location. IEEE
Transactions on Image Processing. 14(9):1351-1359.
Boland, M.V., Murphy, R.F. 2001. A Neural Network Classifier Capable of
Recognizing All Major Subcellular Structures in Fluorescence Microscope
Images of HeLa Cells. Bioinformatics. 17(12):1213-1223.
Murphy, R.F., Boland, M.V., Velliste, M. 2000. Towards a Systematics for
Protein Subcellular Location: Quantitative Description of Protein
Localization Patterns and Automated Analysis of Fluorescence Microscope
Images. Proceedings of the 8th International Conference on Intelligent
Systems for Molecular Biology (ISMB). 8:251-259.
Boland, M.V., Murphy, R.F. 1999. After Sequencing: Quantitative Analysis
of Protein Localization. IEEE Engineering in Medicine and Biology
Magazine. 18(5):115-119.
Markey, M.K., Boland, M.V., Murphy, R.F. 1999. Towards Objective
Selection of Representative Microscope Images. Biophysical Journal.
76:2230-2237.
