Affiliated Faculty

Sonia Cortassa

Research Associate, Institute of Molecular Cardiobiology and the Center for Computational Medicine and Biology, Johns Hopkins School of Medicine

Address:
844 Ross Building, Room 915
720 Rutland Avenue
Baltimore, MD 21205

Phone: (410) 955-2759
Fax: (410) 955-7953
E-mail: scortas1@jhmi.edu

CV

Research Interest Statement

Sonia Cortassa is interested in the general role of Bioenergetics in cellular function. The contribution of bioenergetics in the context of the interactions between cellular processes of different nature like electrical, mechanical and biochemical has been the focus of her studies. In particular she is addressing the interaction between energetic metabolism and EC-coupling in heart cells during normal and disease states.

Another related topic of interest is the organization of cellular metabolism and the effects of compartmentation and channeling.

To address those subjects she uses a combined experimental-theoretical approach with special emphasis on the quantitative aspects that include mathematical modeling, Metabolic Control Analysis and stability and bifurcation analysis.

Publications

Cortassa S., B. O'Rourke, R.L. Winslow, M.A. Aon (2009). "Control and regulation of mitochondrial energetics in an integrated model of cardiomyocyte function." Biophysical Journal, 96(6): 2466-78.

Cortassa S., B. O'Rourke, R.L. Winslow, M.A. Aon (2009). "Control and regulation of integrated mitochondrial function in metabolic and transport networks." Int J Mol Sci., 10(4): 1500-13.

Plank G., L. Zhou, J.L. Greenstein, S. Cortassa, R.L. Winslow, B. O'Rourke, N. Trayanova (2008). "From mitochondrial ion channels toarrhythmias in the heart: computational techniques to bridge the spatio-temporal scales." Philos Transact A Math Phys Eng Sci., 366(1879): 3381-3409.

Winslow R. L., S. Cortassa, J. L. Greenstein (2005). "Using Models of the Myocyte for Functional Interpretation of Cardiac Proteomic Data." J. Physiol., 563(1): 73-81.

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Presentations

Calcium and ADP-mediated signaling of mitochondrial energy supply in a virtual cardiac myocyte model. BMES 2005 Annual Fall Meeting. Baltimore, MD, September 29, 2005

Calcium and ADP-mediated signaling of mitochondrial energy supply in an EC coupling-mitochondrial energetics model. Symposium on Computational Modeling of Cardiac Energetics. Oxfordshire, UK, June 29- July 1, 2005.

An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Gordon Research Conference on Cardiac Regulatory mechanisms. 2002, Abstract selected for oral presentation.

Metabolic and cellular engineering: A meeting place of molecular biology, biochemistry and physiology. Department of Biological Sciences, University of Maryland Baltimore County. November 2001.

Un enfoque dinámico del estudio de la organización en biología. Cátedra de Histología, Embriología y Genética, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Julio 1998.

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