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Affiliated Faculty |
Jeff Gray
Assistant Professor, Department of Chemical & Biomolecular Engineering and Program in Molecular Biophysics, Johns Hopkins University
Address:
208 Maryland Hall
3400 N. Charles Street
Baltimore, MD 21205
Phone: (410) 516-5313
Fax: (410) 516-7308
E-mail: jgray@jhu.edu
Research Interest Statement
A fundamental understanding of protein assembly processes is necessary for both elucidating biological molecular interactions on a genomic scale and designing complex devices capable of assembling themselves from nanoscopic (macromolecular) components. In our lab, we develop numerical models of proteins to predict and rationally design multi-protein structures.
Current Projects
Current projects focus on protein-protein docking, protein-surface interactions, and allostery. The docking project aims to predict the structure of protein complexes given the structures of the individual protein components. The protein-surface interaction project aims to determine the structure of and design individual protein conformations on a surface, toward assembling supported, functional biological/electronic interfaces. Similarly, the allostery project aims to quantify and predict protein motions involved in signaling and switching.
Publications
Daily, M.D., D. Masica, A. Sivasubramanian, S. Somarouthu, and J.J. Gray. (2005) CAPRI rounds 3-5 reveal promising successes and future challenges for RosettaDock. Proteins 60:181-186.
Singh, P., A.M. Mhaka, S.B. Christensen, J.J. Gray, S.R. Denmeade, and J.T. Isaacs. (2005) Applying linear interaction energy method for rational design of non-competitive allosteric inhibitors of the SERCA ATPase. J. Med. Chem. 48:3005-3014.
Gray, J.J. (2004) The interaction of proteins with solid surfaces. Curr. Op. Struct. Biol. 14(1):110-115.
Gray, J.J., S.E. Moughan, T. Kortemme, O. Scheuler-Furman, K.M.S. Misura, A.V. Morozov, and D. Baker. (2003) Protein-protein docking predictions for the CAPRI experiment. Proteins 52(1):118-122.
Gray, J.J., S.E. Moughan, C. Wang, O. Scheuler-Furman, B. Kuhlman, C.A. Rohl, and D. Baker. (2003) Protein-protein docking with simultaneous optimization of rigid body displacement and side chain conformations. J. Mol. Biol. 331(1):281-299.
Presentations
