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Joseph L. Greenstein
Assistant Research Professor, Department of Biomedical Engineering
Center for Cardiovascular Bioinformatics and Modeling
Address:
3400 N. Charles Street
Computational Science & Engineering Building, Room 316b
Baltimore, MD 21218
Phone: (410) 516-5425
Fax: (410) 516-5294
E-mail: jgreenst@jhu.edu
Research Interest Statement
Multi-scale mathematical modeling of the cardiac myocyte for the study of mechanisms underlying integrated cellular physiology in health and disease.
Modeling signaling pathways that regulate cardiac ionic currents and excitation-contraction coupling (e.g. beta-adrenergic, CaMKII, and nitric oxide mediated regulation of channel function).
Stochastic modeling of cardiac myocyte membrane ionic channels, Ca2+ ion diffusion, and excitation-contraction coupling within the cardiac dyad. Development of efficient biophysically based models (known as coupled models) of local control of Ca2+-induced Ca2+ release and regulation of CICR in the cardiac myocyte.
Current Projects
Role of CaMKII in L-type Ca2+ current facilitation and action potential properties.
Investigation of the role of myocyte-fibroblast coupling on action potential properties.
The coupled LCC-RyR (L-type Ca2+ channel – Ryanodine Receptor) model of excitation-contraction coupling.
Investigation of the role of local redundancy in LCC gating on gain of excitation-contraction coupling.
Using spatially detailed myocyte models to understand the role of localization of ion channels, transporters, and signaling proteins to subcellular microdomains on integrative myocyte function.
Publications
Maleckar M.M., J.L. Greenstein, W.R. Giles, N. Trayanova (2009). "K+ current changes account for the rate dependence of the action potential in the human atrial myocyte." Am J Physiol Heart Circ Physiol., 297(4): H1398-410.
Hashambhoy Y.L., R.L. Winslow, J.L. Greenstein (2009). "CaMKII-Induced Shift in Modal Gating Explains L-Type Ca(2+) Current Facilitation: A Modeling Study." Biophysical Journal, 96(5): 1770-85.
Plank G., L. Zhou, J.L. Greenstein, S. Cortassa, R.L. Winslow, B. O'Rourke, N. Trayanova (2008). "From mitochondrial ion channels toarrhythmias in the heart: computational techniques to bridge the spatio-temporal scales." Philos Transact A Math Phys Eng Sci., 366(1879): 3381-3409.
Maleckar M.M., J.L. Greenstein, N.A. Trayanova, W.R. Giles (2008). "Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium." Prog Biophys Mol Biol, 98(2-3): 161-70.
Tanskanen A. J., J. L. Greenstein, A. Chen, S. X. Sun, R. L. Winslow (2007). "Protein Geometry and Placement in the Cardiac Dyad Influence Macroscopic Properties of Calcium-Induced Calcium Release." Biophys J, 92(10): 3379-3396.
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