3400 N. Charles Street
Hackerman Hall, Room 315
Baltimore, MD 21218
Phone: (443) 519-2204
Fax: (410) 516-5294
E-mail: rwinslow | at | jhu.edu
Computational modeling of intracellular signaling, metabolism and electrical excitability in cardiac myocytes.
Integrative modeling of cardiac function in health and disease
Biomedical data representation and database design
Grid-computing and data-sharing
The CardioVascular Research Grid (www.cvrgrid.org)
The Systems Biology of Sudden Cardiac Death (www.icm.jhu.edu/r33/)
The Proteomics of Adaptation to Ischemia and Hypoxia in Heart, Lung, and Blood (www.proteomics.jhu.edu)
Pathobiology of Cardiac Dyssynchrony & Resynchronization
Mitochondrial Function in Ischemic Heart Disease
Tanskanen A. J., J. L. Greenstein, A. Chen, S. X. Sun, R. L. Winslow (2007). "Protein Geometry and Placement in the Cardiac Dyad Influence Macroscopic Properties of Calcium-Induced Calcium Release." Biophys J, 92(10): 3379-3396.
Cortassa S., M. A. Aon, B. O'Rourke, R. Jacques, H. J. Tseng, E. Marban, R. L. Winslow (2006). "A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte." Biophys J., 91(4): 1564-1589.
Greenstein J. L., R. Hinch, R. L. Winslow (2006). "Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte." Biophys J., 90(1): 77-91.
Tanskanen A.J., J. L. Greenstein, B. O'Rourke, R. L. Winslow (2005). "The Role of Stochastic and Modal Gating of Cardiac L-type Ca2+ Channels on Early After-Depolarizations." Biophys J., 88(1): 85-95.
Hinch R., J. L. Greenstein, A.J. Tanskanen, L. Xu, R. L. Winslow (2004). "A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes." Biophys J., 87(6): 3723-3736.
Greenstein J. L., R. L. Winslow (2002). "An Integrative Model of the Cardiac Ventricular Myocyte Incorporating Local Control of Ca2+ Release." Biophys J., 83(6): 2918-45.
"High-Performance Computing and Integrative Modeling of Biological Systems." National Academy of Sciences, Symposium on Potential Impacts of High-End Capability Computing, September 22, 2008. (PDF) (MOV)
"Multi-Scale Modeling of Calcium Signaling in the Cardiac Dyad." Institute for Integrative Systems Biology, Georgia Institute of Technology, March 28, 2008.
"Multi-Scale Modeling of Cardiac Function in Health and Disease." Harvard University School of Engineering, October 24, 2007.
"Computational Medicine in Heart Disease." Predictive Health Symposium, Emory University School of Medicine, December 18-19, 2006.
"Multi-Scale Modeling of Cardiac EC Coupling." Distinguished Lecturer Series, The Cardiovascular Research and Technology Institute, University of Utah, June 1, 2006. (PDF)