William S. Anderson, associate professor of neurosurgery and ICM core faculty member, has received a technology development grant through the Louis B. Thalheimer Fund for Translational Research. 

Anderson and his team have developed ePACStim, an adaptive brain implant system that delivers targeted and customized electrical stimulation to suppress excessive phase amplitude coupling (PAC) in the motor cortex, an electrophysiological biomarker specific to Parkinson’s disease. The minimally invasive device allows for near-real-time wireless monitoring, and has the potential to treat other common neurological conditions marked by increased PAC levels, including Tourette’s syndrome, Alzheimer’s disease and obsessive-compulsive disorder.

The Thalheimer grant will fund enhancements to the ePACStim system, and development of a prototype for a pilot clinical study.

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