Rodolphe Sepulchre, Cambridge University, “Sensitivity Analysis of Neuronal Behaviors”

April 21, 2015 @ 3:00 pm – 4:00 pm
Arellano Theater

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Sensitivity Analysis of Neuronal Behaviors

Rodolphe Sepulchre  is Professor of Engineering at Cambridge University and a fellow of Sidney Sussex College.  His research interests are in nonlinear dynamics, control and optimization.  He is currently Editor-in-Chief of Systems and Control Letters and has been an Associate Editor for  SIAM Journal of Control and Optimization, the Journal of Nonlinear Science, and  Mathematics for Control, Signals, and Systems. In 2008, he was awarded the IEEE Control Systems Society Antonio Ruberti Young Researcher Prize. He is an IEEE fellow and an IEEE CSS distinguished lecturer since 2010.  His current research interests are in nonlinear control and optimization, distributed control and synchronization, and the  analysis  of neuronal behaviors.

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“Sensitivity Analysis of Neuronal Behaviors”

RS-JHReliable neuron activity is ensured by a tight regulation of  ion channels expression. Understanding the causal mechanisms that relate this regulation to physiological and pathological neuronal activity is a necessary step for developing efficient therapies for neurological diseases associated with abnormal nervous system activity. We will discuss a novel methodological framework to quantify the sensitivity of neuronal activity to changes in ion channel densities, either from a detailed conductance-based model or from voltage-clamped experimental data. We will illustrate the generality of the framework and its potential to improve our understanding of the regulation of brain functions and to help in the design of new  pharmacological treatments.

JHU - Institute for Computational Medicine