A new article entitled “Mitochondrial energetics, pH regulation, and ion dynamics: A computaional-experimental approach” from An-Chi Wei of Dr. Raimond Winslow’s lab was highlighted as a featured article in the June 22 issue of Biophysical Journal. In this published article, a computational model of mitochondrial energetics and ion dynamics was presented. With the collaboration with Dr. O’Rourke lab in Cardiology, an experimental-theoretical approach adopted in this work allowed us to validate our computational model. Among many new possibilities, this computational model provides the ability to simulate mitochondrial behavior during dysfunctional states involving changes in pH and ion dynamics, such as ischemia-reperfusion, and assess their impact on the contractile and electrical functions of the cardiac myocyte.

To view the article abstract, Click Here.