Dr. Rachel Karchin has been named a Fellow of the International Society of Computational Biology (ISCB). The ISCB Fellows program recognizes excellence in computational biology. It honors individuals who have made outstanding contributions through leadership, research, and service. She has been recognized as a pioneer in computational cancer genomics because of her development of innovate algorithms for variant interpretation and tumor evolution.

Dr. Karchin created CHASM, the first widely used statistical learning method to distinguish driver from passenger mutations, and led the development of OpenCRAVAT, a widely adopted open-source variant annotation toolkit. Her contributions extend to immuno-oncology, where her deep learning-based BigMHC model advances neoantigen prioritization for precision medicine. Rachel has played key roles in major cancer research initiatives, served on multiple advisory boards, and mentored the next generation of computational biologists.

Dr. Karchin and the other 2025 fellows will be honored during the ISMB / ECCB 2025 conference in Liverpool later this year.