“TCR Repertoire Overlap and Public Clones –

Prediction from Theory and Observation in Data”

Yuval Elhanati, PhD

Senior Research Scientist

Memorial Sloan Kettering Cancer Center

A theoretical physicist in training, my research is dedicated to the quantitative study of the diversity of the adaptive immune system, specifically in the context of cancer and immunotherapy. I design and learn statistical models describing T and B cells populations, to find the characteristics of reacting immune systems, in turn producing algorithms that direct diagnostic and treatment.

Abstract: Large diversity of T cell receptors (TCR) is a defining characteristic of the T cell repertoire. But despite the large number of different TCR each individual possess, public T cell clones, shared between many individuals, are observed in any cohort. In this talk I will present models that can explain and predict TCR overlap, and show how overlap analysis can produce insights on patients data.

Tuesday, March 4, 2025, 4:00pm – 5:00pm

Zoom Link: https://wse.zoom.us/j/99173611677

Homewood Campus, Clark 110

Faculty Hosts: Dr. Rachel Karchin