Seminar Abstract

“Multiscale Electrophysiology in Human Epileptic Networks and Flexible Brain-Computer Interfaces for Epilepsy”

Recent evidence demonstrates that seizures may be generated by submilimeter domains in neocortex that are not imaged by standard clinical electrodes. In the search to localize epileptic networks for surgery or antiepileptic devices the technical challenge is clear: how can we map and decode 100 micron scale electrophysiology in human brain over regions spanning tens of square centimeters or more. In this seminar I will review recent studies of seizure generation in human neocortex, and present a new brain-computer interface platform we have developed to map and modulate this activity at high resolution in-vivo. The platform is composed of active, flexible, conformable electronics developed in collaboration with John Rogers at the University of Illinois, and Jonathan Viventi and NYU/ POLY. I will present high-resolution cortical surface recordings of epileptiform activity recorded with these devices from an acute feline seizure model and their implications for translation to human therapy.

Note: Light lunch will be served starting at 1:00pm. The presentation will begin at 1:30pm.